Varaico: Literature-Extracted Genetic Variants

PLK4

171 papers

RefSeq Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centrio...

Pfam Domains

Pkinaseaa 12–265UCSCProtein kinase domain

Plk4_PB1aa 591–697UCSCPolo-like Kinase 4 Polo Box 1

Plk4_PB2aa 699–807UCSCPolo-like Kinase 4 Polo Box 2

Gene Aliases

HGNC Name

polo like kinase 4

HGNC Previous Symbol

STK18

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_014264.5

p.C779Y

c.2336G>A

Surrounding Variants

1 paper

NM_014264.5

p.T793A

c.2377A>G

2 papers

NM_014264.5

p.I801V

c.2401A>G

1 paper

NM_014264.5

p.A772T

c.2314G>A

2 papers

NM_014264.5

p.S760_L761insAC

c.2278_2282ins6

1 paper

NM_014264.5

p.N759D

c.2275A>G

1 paper

NM_014264.5

p.V758A

c.2273T>C

2 papers

NM_014264.5

p.T751A

c.2251A>G

2 papers

NM_014264.5

p.S749A

c.2245T>G

2 papers

NM_014264.5

p.T746A

c.2236A>G

1 paper

NM_014264.5

p.K745N

c.2235G>C

1 paper

NM_014264.5

p.K745N

c.2235G>T

1 paper

NM_014264.5

p.Q741*

c.2221C>T