Varaico: Literature-Extracted Genetic Variants

PLK4

171 papers

RefSeq Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centrio...

Pfam Domains

Pkinaseaa 12–265UCSCProtein kinase domain

Plk4_PB1aa 591–697UCSCPolo-like Kinase 4 Polo Box 1

Plk4_PB2aa 699–807UCSCPolo-like Kinase 4 Polo Box 2

Gene Aliases

HGNC Name

polo like kinase 4

HGNC Previous Symbol

STK18

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014264.5

p.C880Y

c.2639G>A

Surrounding Variants

1 paper

NM_014264.5

p.S874A

c.2620T>G

2 papers

NM_014264.5

p.S873A

c.2617T>G

1 paper

NM_001190799.2

p.T838I

c.2513C>T

1 paper

NM_014264.5

p.T870A

c.2608A>G

1 paper

NM_014264.5

p.S868A

c.2602T>G

1 paper

NM_014264.5

p.T864A

c.2590A>G

1 paper

NM_014264.5

p.S854_M855Splc

c.2563-56A>G

5 papers

NM_014264.5

p.E830D

c.2490G>C

5 papers

NM_014264.5

p.E830D

c.2490G>T

1 paper

NM_014264.5

p.T828A

c.2482A>G

1 paper

NM_014264.5

p.S824A

c.2470T>G

1 paper

NM_014264.5

p.S821A

c.2461T>G