Varaico: Literature-Extracted Genetic Variants

PLK4

171 papers

RefSeq Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centrio...

Pfam Domains

Pkinaseaa 12–265UCSCProtein kinase domain

Plk4_PB1aa 591–697UCSCPolo-like Kinase 4 Polo Box 1

Plk4_PB2aa 699–807UCSCPolo-like Kinase 4 Polo Box 2

Gene Aliases

HGNC Name

polo like kinase 4

HGNC Previous Symbol

STK18

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014264.5

p.G905A

c.2714G>C

Surrounding Variants

1 paper

NM_014264.5

p.T903A

c.2707A>G

1 paper

NM_014264.5

p.V918delFs

c.2754delT

1 paper

NM_014264.5

p.S924A

c.2770T>G

1 paper

NM_014264.5

p.S925A

c.2773T>G

1 paper

NM_014264.5

p.T929A

c.2785A>G

1 paper

NM_014264.5

p.S930insFs

c.2789dupC

1 paper

NM_014264.5

p.R937fs

c.2809_2810fs

4 papers

NM_014264.5

p.R937Splc

c.2811-5C>G

2 papers

NM_014264.5

p.S956A

c.2866T>G

1 paper

NM_014264.5

p.S957A

c.2869T>G

1 paper

NM_001190799.2

p.M929V

c.2785A>G

1 paper

NM_014264.5

p.C880Y

c.2639G>A