Varaico: Literature-Extracted Genetic Variants

POLR2B

123 papers

RefSeq Summary

This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This sub...

Pfam Domains

RNA_pol_Rpb2_1aa 38–442UCSCRNA polymerase beta subunit

RNA_pol_Rpb2_2aa 201–394UCSCRNA polymerase Rpb2, domain 2

RNA_pol_Rpb2_3aa 468–532UCSCRNA polymerase Rpb2, domain 3

RNA_pol_Rpb2_4aa 567–629UCSCRNA polymerase Rpb2, domain 4

RNA_pol_Rpb2_5aa 653–700UCSCRNA polymerase Rpb2, domain 5

RNA_pol_Rpb2_6aa 707–1080UCSCRNA polymerase Rpb2, domain 6

Gene Aliases

HGNC Name

RNA polymerase II subunit B

HGNC Alias Symbol

RPB2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000938.3

p.D61D

c.183C>T

Surrounding Variants

1 paper

NM_000938.3

p.D61Y

c.181G>T

1 paper

NM_000938.3

p.P63S

c.187C>T

1 paper

NM_000938.3

p.D66N

c.196G>A

1 paper

NM_000938.3

p.A69S

c.205G>T

1 paper

NM_000938.3

p.E80D

c.240A>C

1 paper

NM_000938.3

p.E80D

c.240A>T

1 paper

NM_000938.3

p.P81S

c.241C>T

1 paper

NM_000938.3

p.K37R

c.110A>G

1 paper

NM_000938.3

p.Y84C

c.251A>G

1 paper

NM_000938.3

p.K95M

c.284A>T

2 papers

NM_000938.3

p.P123P

c.369G>C

1 paper

NM_000938.3

p.D127H

c.379G>C