Varaico: Literature-Extracted Genetic Variants

POLR2B

123 papers

RefSeq Summary

This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This sub...

Pfam Domains

RNA_pol_Rpb2_1aa 38–442UCSCRNA polymerase beta subunit

RNA_pol_Rpb2_2aa 201–394UCSCRNA polymerase Rpb2, domain 2

RNA_pol_Rpb2_3aa 468–532UCSCRNA polymerase Rpb2, domain 3

RNA_pol_Rpb2_4aa 567–629UCSCRNA polymerase Rpb2, domain 4

RNA_pol_Rpb2_5aa 653–700UCSCRNA polymerase Rpb2, domain 5

RNA_pol_Rpb2_6aa 707–1080UCSCRNA polymerase Rpb2, domain 6

Gene Aliases

HGNC Name

RNA polymerase II subunit B

HGNC Alias Symbol

RPB2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000938.3

p.D127H

c.379G>C

Surrounding Variants

2 papers

NM_000938.3

p.P123P

c.369G>C

3 papers

NM_000938.3

p.G136C

c.406G>T

1 paper

NM_000938.3

p.G150delFs

c.448_449delGG

1 paper

NM_000938.3

p.G150fs

c.448_449fs

1 paper

NM_000938.3

p.I154delFs

c.461_462delTT

1 paper

NM_000938.3

p.M155L

c.463A>C

1 paper

NM_000938.3

p.M155L

c.463A>T

1 paper

NM_000938.3

p.T159I

c.476C>T

1 paper

NM_000938.3

p.Y160D

c.478T>G

1 paper

NM_000938.3

p.L163L

c.489G>A

1 paper

NM_000938.3

p.D170Y

c.508G>T

1 paper

NM_000938.3

p.D170V

c.509A>T