Varaico: Literature-Extracted Genetic Variants

POLR2B

123 papers

RefSeq Summary

This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This sub...

Pfam Domains

RNA_pol_Rpb2_1aa 38–442UCSCRNA polymerase beta subunit

RNA_pol_Rpb2_2aa 201–394UCSCRNA polymerase Rpb2, domain 2

RNA_pol_Rpb2_3aa 468–532UCSCRNA polymerase Rpb2, domain 3

RNA_pol_Rpb2_4aa 567–629UCSCRNA polymerase Rpb2, domain 4

RNA_pol_Rpb2_5aa 653–700UCSCRNA polymerase Rpb2, domain 5

RNA_pol_Rpb2_6aa 707–1080UCSCRNA polymerase Rpb2, domain 6

Gene Aliases

HGNC Name

RNA polymerase II subunit B

HGNC Alias Symbol

RPB2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000938.3

p.Q582*

c.1744C>T

Surrounding Variants

1 paper

NM_000938.3

p.R591T

c.1772G>C

1 paper

NM_000938.3

p.R592C

c.1774C>T

1 paper

NM_000938.3

p.D595Y

c.1783G>T

1 paper

NM_000938.3

p.K566N

c.1698G>C

1 paper

NM_000938.3

p.K566N

c.1698G>T

2 papers

NM_000938.3

p.A564T

c.1690G>A

1 paper

NM_000938.3

p.P558S

c.1672C>T

1 paper

NM_000938.3

p.E547*

c.1639G>T

1 paper

NM_000938.3

p.V523E

c.1568T>A

1 paper

NM_000938.3

p.L522F

c.1564C>T

1 paper

NM_000938.3

p.H518Q

c.1554T>A

1 paper

NM_000938.3

p.H518Q

c.1554T>G