POU class 6 homeobox 2

RPF-1

POU domain, class 6, transcription factor 2

Retina-derived POU-domain factor-1

Retina-derived POU domain factor 1

Pou domain - N-terminal to homeobox domain

This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009].

Varaico: Literature-Extracted Genetic Variants

POU6F2

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbol