protein phosphatase, Mg2+/Mn2+ dependent 1L

PP2CE

protein phosphatase 1 (formerly 2C)-like

protein phosphatase, Mg2+/Mn2+ dependent, 1L

PP2Cepsilon

Protein phosphatase 2C epsilon isoform

Protein phosphatase 1L

Protein phosphatase 1-like

Protein phosphatase 2C isoform epsilon

PP2C-epsilon

The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].

Varaico: Literature-Extracted Genetic Variants

PPM1L

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbol