Varaico: Literature-Extracted Genetic Variants

PRKAR2A

56 papers

RefSeq Summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation...

Pfam Domains

RIIaaa 8–45UCSCRegulatory subunit of type II PKA R-subunit

cNMP_bindingaa 157–244UCSCCyclic nucleotide-binding domain

cNMP_bindingaa 279–373UCSCCyclic nucleotide-binding domain

Gene Aliases

HGNC Name

protein kinase cAMP-dependent type II regulatory subunit alpha

HGNC Previous Symbol

PRKAR2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_004157.4

p.Y282C

c.845A>G

Surrounding Variants

1 paper

NM_004157.4

p.Q291E

c.871C>G

1 paper

NM_004157.4

p.L265R

c.794T>G

1 paper

NM_004157.4

p.K247R

c.740A>G

1 paper

NM_004157.4

p.I241L

c.721A>C

1 paper

NM_004157.4

p.R234W

c.700C>T

1 paper

NM_004157.4

p.L232Q

c.695T>A

1 paper

NM_004157.4

p.W230*

c.690G>A

1 paper

NM_004157.4

p.P216L

c.647C>T

1 paper

NM_004157.4

p.Y213H

c.637T>C

1 paper

NM_004157.4

p.F206C

c.617T>G

1 paper

NM_004157.4

p.S205C

c.613A>T

1 paper

NM_004157.4

p.R203C

c.607C>T