Varaico: Literature-Extracted Genetic Variants

PRKCA

332 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide v...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 339–597UCSCProtein kinase domain

Pkinase_Caa 623–658UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C alpha

HGNC Previous Symbol

PKCA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002737.3

p.W58R

c.172T>A

Surrounding Variants

1 paper

NM_002737.3

p.W58L

c.173G>T

1 paper

NM_002737.3

p.D55A

c.164A>C

1 paper

NM_002737.3

p.D55N

c.163G>A

1 paper

NM_002737.3

p.T54P

c.160A>C

1 paper

NM_002737.3

p.P47R

c.140C>G

1 paper

NM_002737.3

p.P47A

c.139C>G

1 paper

NM_002737.3

p.P47S

c.139C>T

1 paper

NM_002737.3

p.K45R

c.134A>G

1 paper

NM_002737.3

p.K45Q

c.133A>C

1 paper

NM_002737.3

p.R42C

c.124C>T

1 paper

NM_002737.3

p.H37L

c.110A>T

1 paper

NM_002737.3

p.V31M

c.91G>A