Varaico: Literature-Extracted Genetic Variants

PRKCA

332 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide v...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 339–597UCSCProtein kinase domain

Pkinase_Caa 623–658UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C alpha

HGNC Previous Symbol

PKCA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002737.3

p.D357N

c.1069G>A

Surrounding Variants

1 paper

NM_002737.3

p.M354K

c.1061T>A

1 paper

NM_002737.3

p.M354T

c.1061T>C

1 paper

NM_002737.3

p.G360S

c.1078G>A

1 paper

NM_002737.3

p.T361K

c.1082C>A

1 paper

NM_002737.3

p.E362*

c.1084G>T

2 papers

NM_002737.3

p.E363K

c.1087G>A

1 paper

NM_002737.3

p.E363G

c.1088A>G

1 paper

NM_002737.3

p.K368insFs

c.1102_1103insC

6 papers

NM_002737.3

p.K368R

c.1103A>G

1 paper

NM_002737.3

p.K368N

c.1104A>C

1 paper

NM_002737.3

p.K368N

c.1104A>T

1 paper

NM_002737.3

p.K371R

c.1112A>G