Varaico: Literature-Extracted Genetic Variants

PRKCA

332 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide v...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 339–597UCSCProtein kinase domain

Pkinase_Caa 623–658UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C alpha

HGNC Previous Symbol

PKCA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002737.3

p.G534R

c.1600G>C

Surrounding Variants

1 paper

NM_002737.3

p.G534R

c.1600G>A

1 paper

NM_002737.3

p.Y529C

c.1586A>G

1 paper

NM_002737.3

p.Y529F

c.1586A>T

1 paper

NM_002737.3

p.V526A

c.1577T>C

1 paper

NM_002737.3

p.G525D

c.1574G>A

1 paper

NM_002737.3

p.G525R

c.1573G>C

1 paper

NM_002737.3

p.A523V

c.1568C>T

1 paper

NM_002737.3

p.A523S

c.1567G>T

3 papers

NM_002737.3

p.P514L

c.1541C>T

1 paper

NM_002737.3

p.A511T

c.1531G>A