Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002738.7

p.A6T

c.16G>A

Surrounding Variants

1 paper

NM_002738.7

p.A5V

c.14C>T

1 paper

NM_002738.7

p.P4P

c.12G>A

2 papers

NM_002738.7

p.P4P

c.12G>C

1 paper

NM_002738.7

p.G7_P8insFs

c.21_22ins5

1 paper

NM_002738.7

p.P4S

c.10C>T

1 paper

NM_002738.7

p.P9delFs

c.25delC

1 paper

NM_002738.7

p.E14*

c.40G>T

1 paper

NM_002738.7

p.T17S

c.49A>T

1 paper

NM_002738.7

p.T17N

c.50C>A

1 paper

NM_002738.7

p.V18E

c.53T>A

1 paper

NM_002738.7

p.R19L

c.56G>T

1 paper

NM_002738.7

p.F20L

c.58T>C