Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002738.7

p.L26R

c.77T>G

Surrounding Variants

1 paper

NM_002738.7

p.R27R

c.79C>A

2 papers

NM_002738.7

p.A25V

c.74C>T

1 paper

NM_002738.7

p.K29_N30del1

c.87_89delGAA

1 paper

NM_002738.7

p.K23N

c.69A>C

1 paper

NM_002738.7

p.K23N

c.69A>T

1 paper

NM_002738.7

p.K29insFs

c.87dupG

1 paper

NM_002738.7

p.K29T

c.86A>C

3 papers

NM_002738.7

p.K29N

c.87G>C

2 papers

NM_002738.7

p.K29N

c.87G>T

6 papers

NM_002738.7

p.R22H

c.65G>A

1 paper

NM_002738.7

p.R22L

c.65G>T

1 paper

NM_002738.7

p.F20L

c.60C>A