Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002738.7

p.K35K

c.105G>A

Surrounding Variants

1 paper

NM_002738.7

p.T40I

c.119C>T

3 papers

NM_002738.7

p.K29N

c.87G>C

2 papers

NM_002738.7

p.K29N

c.87G>T

1 paper

NM_002738.7

p.K29insFs

c.87dupG

1 paper

NM_002738.7

p.K29T

c.86A>C

1 paper

NM_002738.7

p.R42G

c.124C>G

2 papers

NM_002738.7

p.R42H

c.125G>A

2 papers

NM_002738.7

p.R42P

c.125G>C

1 paper

NM_002738.7

p.K29_N30del1

c.87_89delGAA

1 paper

NM_002738.7

p.R27R

c.79C>A

1 paper

NM_002738.7

p.L26R

c.77T>G

2 papers

NM_002738.7

p.A25V

c.74C>T