Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002738.7

p.C50S

c.149G>C

Surrounding Variants

1 paper

NM_002738.7

p.C50F

c.149G>T

1 paper

NM_002738.7

p.C50S

c.148T>A

1 paper

NM_002738.7

p.S51G

c.151A>G

2 papers

NM_002738.7

p.S51C

c.151A>T

1 paper

NM_002738.7

p.S51T

c.152G>C

1 paper

NM_002738.7

p.P47R

c.140C>G

1 paper

NM_002738.7

p.Q46*

c.136C>T

1 paper

NM_002738.7

p.D55H

c.163G>C

1 paper

NM_002738.7

p.D55G

c.164A>G

1 paper

NM_002738.7

p.I57T

c.170T>C

2 papers

NM_002738.7

p.R42H

c.125G>A

2 papers

NM_002738.7

p.R42P

c.125G>C