Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_002738.7

p.G92V

c.275G>T

Surrounding Variants

2 papers

NM_002738.7

p.P93L

c.278C>T

1 paper

NM_002738.7

p.A94S

c.280G>T

1 paper

NM_002738.7

p.D90Y

c.268G>T

1 paper

NM_002738.7

p.V82A

c.245T>C

1 paper

NM_002738.7

p.V82F

c.244G>T

1 paper

NM_002738.7

p.H79delFs

c.237delT

1 paper

NM_002738.7

p.H79delFs

c.235delC

1 paper

NM_002738.7

p.H75Q

c.225C>A

1 paper

NM_002738.7

p.H75Q

c.225C>G

2 papers

NM_002738.7

p.V74M

c.220G>A

1 paper

NM_002738.7

p.F72Y

c.215T>A