Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_002738.7

p.N182K

c.546C>G

Surrounding Variants

1 paper

NM_002738.7

p.N182N

c.546C>T

1 paper

NM_002738.7

p.V184E

c.551T>A

1 paper

NM_002738.7

p.P194L

c.581C>T

1 paper

NM_002738.7

p.V196I

c.586G>A

1 paper

NM_002738.7

p.L198M

c.592C>A

1 paper

NM_002738.7

p.P202P

c.606C>T

1 paper

NM_002738.7

p.D203N

c.607G>A

1 paper

NM_002738.7

p.K205E

c.613A>G

1 paper

NM_002738.7

p.S208N

c.623G>A

1 paper

NM_002738.7

p.K209E

c.625A>G

1 paper

NM_002738.7

p.Q210H

c.630G>T

1 paper

NM_002738.7

p.K211E

c.631A>G