Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_002738.7

p.D235N

c.703G>A

Surrounding Variants

1 paper

NM_002738.7

p.S234S

c.702G>A

1 paper

NM_002738.7

p.D248N

c.742G>A

1 paper

NM_002738.7

p.I263F

c.787A>T

1 paper

NM_002738.7

p.E265K

c.793G>A

1 paper

NM_002738.7

p.G273G

c.819C>T

1 paper

NM_002738.7

p.R228K

c.683G>A

1 paper

NM_002738.7

p.E222*

c.664G>T

1 paper

NM_002738.7

p.L219L

c.657C>G

1 paper

NM_002738.7

p.K211N

c.633G>C

1 paper

NM_002738.7

p.K211N

c.633G>T

1 paper

NM_002738.7

p.K211E

c.631A>G

1 paper

NM_002738.7

p.Q210H

c.630G>T