Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002738.7

p.R336Q

c.1007G>A

Surrounding Variants

1 paper

NM_002738.7

p.R336L

c.1007G>T

1 paper

NM_002738.7

p.R336W

c.1006C>T

1 paper

NM_002738.7

p.G332A

c.995G>C

1 paper

NM_002738.7

p.G332V

c.995G>T

2 papers

NM_002738.7

p.D341N

c.1021G>A

1 paper

NM_002738.7

p.N330K

c.990C>A

1 paper

NM_002738.7

p.N330K

c.990C>G

1 paper

NM_002738.7

p.L348Q

c.1043T>A

1 paper

NM_002738.7

p.G349W

c.1045G>T

8 papers

NM_002738.7

p.S352G

c.1054A>G

1 paper

NM_002738.7

p.K320R

c.959A>G

1 paper

NM_002738.7

p.S352N

c.1055G>A