Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002738.7

p.Y417H

c.1249T>C

Surrounding Variants

1 paper

NM_002738.7

p.R415S

c.1243C>A

1 paper

NM_002738.7

p.Y422C

c.1265A>G

1 paper

NM_002738.7

p.V423M

c.1267G>A

1 paper

NM_002738.7

p.V423V

c.1269G>A

1 paper

NM_002738.7

p.G426S

c.1276G>A

2 papers

NM_002738.7

p.G426R

c.1276G>C

1 paper

NM_002738.7

p.G426D

c.1277G>A

13 papers

NM_002738.7

p.D427N

c.1279G>A

1 paper

NM_002738.7

p.D427G

c.1280A>G

1 paper

NM_002738.7

p.Q433R

c.1298A>G

1 paper

NM_002738.7

p.Q433H

c.1299G>C

1 paper

NM_002738.7

p.Q433H

c.1299G>T