Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002738.7

p.F629I

c.1885T>A

Surrounding Variants

6 papers

NM_002738.7

p.D630N

c.1888G>A

1 paper

NM_002738.7

p.D630H

c.1888G>C

3 papers

NM_002738.7

p.D630Y

c.1888G>T

1 paper

NM_002738.7

p.D630G

c.1889A>G

1 paper

NM_002738.7

p.E627*

c.1879G>T

1 paper

NM_002738.7

p.R624Q

c.1871G>A

2 papers

NM_002738.7

p.T634A

c.1900A>G

1 paper

NM_002738.7

p.H636Q

c.1908T>A

1 paper

NM_002738.7

p.H636Q

c.1908T>G

5 papers

NM_002738.7

p.T641A

c.1921A>G

1 paper

NM_002738.7

p.P643S

c.1927C>T

1 paper

NM_002738.7

p.D644N

c.1930G>A