Varaico: Literature-Extracted Genetic Variants

PRKCD

259 papers

RefSeq Summary

The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor su...

Pfam Domains

PKC_C2aa 4–112UCSCProtein kinase C delta/epsilon/eta/theta, C2 domain

C1_1aa 159–211UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 231–283UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

Pkinaseaa 349–603UCSCProtein kinase domain

Pkinase_Caa 624–665UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C delta

HGNC Previous Name

protein kinase C, delta

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_006254.4

p.R614W

c.1840C>T

Surrounding Variants

1 paper

NM_006254.4

p.R615R

c.1843A>C

1 paper

NM_006254.4

p.W608S

c.1823G>C

3 papers

NM_001354678.2

p.P635P

c.1905T>C

NM_001354676.2

p.P638P

c.1914T>C

NM_006254.4

p.P619P

c.1857T>C

1 paper

NM_006254.4

p.H600Y

c.1798C>T

1 paper

NM_001354678.2

p.I613M

c.1839C>G

4 papers

NM_006254.4

p.T594T

c.1782C>G

NM_001354678.2

p.T610T

c.1830C>G

NM_001354676.2

p.T613T

c.1839C>G

1 paper

NM_006254.4

p.K581_L582Splc

c.1743+70T>C

1 paper

NM_006254.4

p.K581_L582Splc

c.1743+29T>G

2 papers

NM_006254.4

p.K581_L582Splc

c.1743+8C>T

1 paper

NM_001354678.2

p.I594M

c.1782C>G

1 paper

NM_006254.4

p.K576insFs

c.1726dupA

1 paper

NM_001354676.2

p.S594S

c.1782C>G