Varaico: Literature-Extracted Genetic Variants

PRKCE

136 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide v...

Pfam Domains

C2aa 6–119UCSCC2 domain

C1_1aa 170–223UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 243–295UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

Pkinaseaa 408–668UCSCProtein kinase domain

Pkinase_Caa 689–730UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C epsilon

HGNC Previous Name

protein kinase C, epsilon

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005400.3

p.R364W

c.1090C>T

Surrounding Variants

1 paper

NM_005400.3

p.I363I

c.1089T>C

1 paper

NM_005400.3

p.E360*

c.1078G>T

2 papers

NM_005400.3

p.S368A

c.1102T>G

1 paper

NM_005400.3

p.E355Splc

c.1064-33A>G

1 paper

NM_005400.3

p.P389S

c.1165C>T

1 paper

NM_005400.3

p.E394K

c.1180G>A

1 paper

NM_005400.3

p.K401Q

c.1201A>C

1 paper

NM_005400.3

p.R402C

c.1204C>T

1 paper

NM_005400.3

p.N409D

c.1225A>G

1 paper

NM_005400.3

p.K412K

c.1236G>A

1 paper

NM_005400.3

p.K421_V422Splc

c.1264-274T>C

1 paper

NM_005400.3

p.S346A

c.1036T>G