Varaico: Literature-Extracted Genetic Variants

PRKCE

136 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide v...

Pfam Domains

C2aa 6–119UCSCC2 domain

C1_1aa 170–223UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 243–295UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

Pkinaseaa 408–668UCSCProtein kinase domain

Pkinase_Caa 689–730UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C epsilon

HGNC Previous Name

protein kinase C, epsilon

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005400.3

p.A519T

c.1555G>A

Surrounding Variants

2 papers

NM_005400.3

p.H524H

c.1572C>T

5 papers

NM_005400.3

p.R510Q

c.1529G>A

1 paper

NM_005400.3

p.V528L

c.1582G>C

1 paper

NM_005400.3

p.P507A

c.1519C>G

1 paper

NM_005400.3

p.E506K

c.1516G>A

2 papers

NM_005400.3

p.R500C

c.1498C>T

1 paper

NM_005400.3

p.D493N

c.1477G>A

1 paper

NM_005400.3

p.Y488C

c.1463A>G

1 paper

NM_005400.3

p.E487K

c.1459G>A

1 paper

NM_005400.3

p.V485I

c.1453G>A