Varaico: Literature-Extracted Genetic Variants

PRKCG

309 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 36–88UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 101–153UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 351–613UCSCProtein kinase domain

Pkinase_Caa 640–675UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C gamma

HGNC Previous Symbols

PKCG; SCA14

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002739.5

p.R104C

c.310C>T

Surrounding Variants

7 papers

NM_002739.5

p.H106P

c.317A>C

22 papers

NM_002739.5

p.H101Q

c.303C>A

22 papers

NM_002739.5

p.H101Q

c.303C>G

10 papers

NM_002739.5

p.H101R

c.302A>G

37 papers

NM_002739.5

p.H101Y

c.301C>T

1 paper

NM_002739.5

p.Y108C

c.323A>G

1 paper

NM_002739.5

p.T112P

c.334A>C

1 paper

NM_002739.5

p.D96N

c.286G>A

5 papers

NM_002739.5

p.F113_C114del1

c.338_340delTCT

17 papers

NM_002739.5

p.C114Y

c.341G>A

1 paper

NM_002739.5

p.C114F

c.341G>T

1 paper

NM_002739.5

p.D115N

c.343G>A