Varaico: Literature-Extracted Genetic Variants

PRKCG

309 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 36–88UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 101–153UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 351–613UCSCProtein kinase domain

Pkinase_Caa 640–675UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C gamma

HGNC Previous Symbols

PKCG; SCA14

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002739.5

p.G128R

c.382G>C

Surrounding Variants

38 papers

NM_002739.5

p.G128D

c.383G>A

4 papers

NM_002739.5

p.Q127P

c.380A>C

24 papers

NM_002739.5

p.Q127R

c.380A>G

3 papers

NM_002739.5

p.C131S

c.391T>A

14 papers

NM_002739.5

p.C131R

c.391T>C

14 papers

NM_002739.5

p.C131Y

c.392G>A

3 papers

NM_002739.5

p.C131S

c.392G>C

1 paper

NM_002739.5

p.S132F

c.395C>T

15 papers

NM_002739.5

p.G123E

c.368G>A

3 papers

NM_002739.5

p.G123A

c.368G>C

3 papers

NM_002739.5

p.G123V

c.368G>T

16 papers

NM_002739.5

p.G123R

c.367G>A