Varaico: Literature-Extracted Genetic Variants

PRKCG

309 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 36–88UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 101–153UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 351–613UCSCProtein kinase domain

Pkinase_Caa 640–675UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C gamma

HGNC Previous Symbols

PKCG; SCA14

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002739.5

p.V138M

c.412G>A

Surrounding Variants

28 papers

NM_002739.5

p.V138E

c.413T>A

1 paper

NM_002739.5

p.V138G

c.413T>G

9 papers

NM_002739.5

p.H139Q

c.417C>A

9 papers

NM_002739.5

p.H139Q

c.417C>G

3 papers

NM_002739.5

p.R140Q

c.419G>A

1 paper

NM_002739.5

p.R141C

c.421C>T

15 papers

NM_002739.5

p.C142S

c.424T>A

4 papers

NM_002739.5

p.C134R

c.400T>C

8 papers

NM_002739.5

p.C142G

c.424T>G

1 paper

NM_002739.5

p.C133*

c.399C>A

15 papers

NM_002739.5

p.C142S

c.425G>C

5 papers

NM_002739.5

p.C150R

c.448T>C