Varaico: Literature-Extracted Genetic Variants

PRKCG

309 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 36–88UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 101–153UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 351–613UCSCProtein kinase domain

Pkinase_Caa 640–675UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C gamma

HGNC Previous Symbols

PKCG; SCA14

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002739.5

p.I165L

c.493A>C

Surrounding Variants

1 paper

NM_002739.5

p.A170V

c.509C>T

1 paper

NM_002739.5

p.G159R

c.475G>A

1 paper

NM_002739.5

p.G159R

c.475G>C

1 paper

NM_002739.5

p.R158C

c.472C>T

6 papers

NM_002739.5

p.I173S

c.518T>G

1 paper

NM_002739.5

p.H174D

c.520C>G

4 papers

NM_002739.5

p.E156K

c.466G>A

10 papers

NM_002739.5

p.H174P

c.521A>C

1 paper

NM_002739.5

p.H154_T155insFs

c.462_463insG

1 paper

NM_002739.5

p.H154L

c.461A>T

6 papers

NM_002739.5

p.D153V

c.458A>T

1 paper

NM_002739.5

p.V177I

c.529G>A