Varaico: Literature-Extracted Genetic Variants

PRKCG

309 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 36–88UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 101–153UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 351–613UCSCProtein kinase domain

Pkinase_Caa 640–675UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C gamma

HGNC Previous Symbols

PKCG; SCA14

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_002739.5

p.K359R

c.1076A>G

Surrounding Variants

18 papers

NM_002739.5

p.G360S

c.1078G>A

29 papers

NM_002739.5

p.S361G

c.1081A>G

1 paper

NM_002739.5

p.S361C

c.1081A>T

1 paper

NM_002739.5

p.F362L

c.1084T>C

2 papers

NM_002739.5

p.V356F

c.1066G>T

1 paper

NM_002739.5

p.F362L

c.1086T>A

1 paper

NM_002739.5

p.F362L

c.1086T>G

1 paper

NM_002739.5

p.M355I

c.1065G>A

1 paper

NM_002739.5

p.M355I

c.1065G>C

1 paper

NM_002739.5

p.M355I

c.1065G>T

1 paper

NM_002739.5

p.L354L

c.1062C>G

1 paper

NM_002739.5

p.L354H

c.1061T>A