Varaico: Literature-Extracted Genetic Variants

PRKCG

309 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 36–88UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 101–153UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 351–613UCSCProtein kinase domain

Pkinase_Caa 640–675UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C gamma

HGNC Previous Symbols

PKCG; SCA14

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

24 papers

NM_002739.5

p.F643L

c.1929T>A

Surrounding Variants

24 papers

NM_002739.5

p.F643L

c.1929T>G

2 papers

NM_002739.5

p.F643S

c.1928T>C

4 papers

NM_002739.5

p.F643C

c.1928T>G

24 papers

NM_002739.5

p.F643L

c.1927T>C

1 paper

NM_002739.5

p.F647S

c.1940T>C

1 paper

NM_002739.5

p.F647F

c.1941C>T

1 paper

NM_002739.5

p.R649L

c.1946G>T

1 paper

NM_002739.5

p.A651V

c.1952C>T

1 paper

NM_002739.5

p.T655A

c.1963A>G

9 papers

NM_002739.5

p.R659S

c.1975C>A

1 paper

NM_002739.5

p.Q667*

c.1999C>T

2 papers

NM_002739.5

p.D669H

c.2005G>C