Varaico: Literature-Extracted Genetic Variants

PRKCH

121 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide v...

Pfam Domains

C2aa 10–124UCSCC2 domain

C1_1aa 172–225UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 246–298UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

Pkinaseaa 355–614UCSCProtein kinase domain

Pkinase_Caa 635–676UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C eta

HGNC Previous Symbol

PRKCL

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006255.5

p.Q61H

c.183G>T

Surrounding Variants

1 paper

NM_006255.5

p.Q61H

c.183G>C

1 paper

NM_006255.5

p.Q61R

c.182A>G

1 paper

NM_006255.5

p.Q61L

c.182A>T

2 papers

NM_006255.5

p.K65R

c.194A>G

1 paper

NM_006255.5

p.G55A

c.164G>C

1 paper

NM_006255.5

p.V49V

c.147G>A

1 paper

NM_006255.5

p.A85T

c.253G>A

1 paper

NM_006255.5

p.H88P

c.263A>C

1 paper

NM_006255.5

p.D95D

c.285C>T

1 paper

NM_006255.5

p.Q23*

c.67C>T

5 papers

NM_006255.5

p.A19V

c.56C>T

1 paper

NM_006255.5

p.A19T

c.55G>A