Varaico: Literature-Extracted Genetic Variants

PRKCH

121 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide v...

Pfam Domains

C2aa 10–124UCSCC2 domain

C1_1aa 172–225UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 246–298UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

Pkinaseaa 355–614UCSCProtein kinase domain

Pkinase_Caa 635–676UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C eta

HGNC Previous Symbol

PRKCL

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006255.5

p.S365C

c.1093A>T

Surrounding Variants

1 paper

NM_006255.5

p.G362A

c.1085G>C

1 paper

NM_006255.5

p.R330Q

c.989G>A

1 paper

NM_006255.5

p.S326L

c.977C>T

1 paper

NM_006255.5

p.S320_K321Splc

c.961-10A>C

20 papers

NM_006255.5

p.V374I

c.1120G>A

1 paper

NM_006255.5

p.V374V

c.1122A>C

1 paper

NM_006255.5

p.A382V

c.1145C>T

1 paper

NM_006255.5

p.L392M

c.1174C>A

2 papers

NM_006255.5

p.D394G

c.1181A>G

2 papers

NM_006255.5

p.A410S

c.1228G>T

1 paper

NM_006255.5

p.S320L

c.959C>T

1 paper

NM_006255.5

p.G308R

c.922G>A