proline rich and Gla domain 1

PRGP1

proline-rich Gla (G-carboxyglutamic acid) polypeptide 1

Transmembrane gamma-carboxyglutamic acid protein 1

Proline-rich gamma-carboxyglutamic acid protein 1

Proline-rich Gla protein 1

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010].

Varaico: Literature-Extracted Genetic Variants

PRRG1

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbol