Varaico: Literature-Extracted Genetic Variants

PTGS2

723 papers

RefSeq Summary

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of...

Pfam Domains

An_peroxidaseaa 204–562UCSCAnimal haem peroxidase

Gene Aliases

HGNC Name

prostaglandin-endoperoxide synthase 2

HGNC Previous Name

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000963.4

p.R499W

c.1495C>T

Surrounding Variants

1 paper

NM_000963.4

p.P500S

c.1498C>T

1 paper

NM_000963.4

p.K497N

c.1491G>T

1 paper

NM_000963.4

p.K497N

c.1491G>C

1 paper

NM_000963.4

p.E496A

c.1487A>C

1 paper

NM_000963.4

p.L494insFs

c.1480_1481insC

1 paper

NM_000963.4

p.G505D

c.1514G>A

1 paper

NM_000963.4

p.E506D

c.1518A>T

1 paper

NM_000963.4

p.E506D

c.1518A>C

1 paper

NM_000963.4

p.I484_Y490del0

c.1452_1469del18

2 papers

NM_000963.4

p.M508T

c.1523T>C

1 paper

NM_000963.4

p.L489L

c.1467G>C

1 paper

NM_000963.4

p.V509I

c.1525G>A