Varaico: Literature-Extracted Genetic Variants

PTGS2

723 papers

RefSeq Summary

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of...

Pfam Domains

An_peroxidaseaa 204–562UCSCAnimal haem peroxidase

Gene Aliases

HGNC Name

prostaglandin-endoperoxide synthase 2

HGNC Previous Name

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000963.4

p.D348N

c.1042G>A

Surrounding Variants

1 paper

NM_000963.4

p.F343_F347delFs

c.1028_1041del14

1 paper

NM_000963.4

p.L351I

c.1051C>A

1 paper

NM_000963.4

p.F343F

c.1029C>T

1 paper

NM_000963.4

p.H342Q

c.1026C>G

1 paper

NM_000963.4

p.H342Q

c.1026C>A

2 papers

NM_000963.4

p.Y341C

c.1022A>G

1 paper

NM_000963.4

p.K355insFs

c.1065dupA

1 paper

NM_000963.4

p.Q356L

c.1067A>T

1 paper

NM_000963.4

p.F357L

c.1069T>C

1 paper

NM_000963.4

p.Q358R

c.1073A>G

1 paper

NM_000963.4

p.H337R

c.1010A>G

1 paper

NM_000963.4

p.Y359*

c.1077C>G