Varaico: Literature-Extracted Genetic Variants

PTPN11

3,412 papers

RefSeq Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell gro...

Pfam Domains

SH2aa 6–81UCSCSH2 domain

SH2aa 112–197UCSCSH2 domain

Y_phosphataseaa 273–520UCSCProtein-tyrosine phosphatase

Gene Aliases

HGNC Name

protein tyrosine phosphatase non-receptor type 11

HGNC Previous Symbol

NS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002834.5

p.R5I

c.14G>T

Surrounding Variants

1 paper

NM_002834.5

p.R5K

c.14G>A

1 paper

NM_002834.5

p.R5T

c.14G>C

1 paper

NM_002834.5

p.R5S

c.15A>C

1 paper

NM_002834.5

p.R5S

c.15A>T

1 paper

NM_002834.5

p.R5Splc

c.14+1G>A

24 papers

NM_002834.5

p.R4R

c.12G>A

20 papers

NM_002834.5

p.R4R

c.12G>C

3 papers

NM_002834.5

p.R4Q

c.11G>A

2 papers

NM_002834.5

p.R4P

c.11G>C

2 papers

NM_002834.5

p.R4L

c.11G>T

4 papers

NM_002834.5

p.R4G

c.10C>G

2 papers

NM_002834.5

p.R4W

c.10C>T