Varaico: Literature-Extracted Genetic Variants

PTPN11

3,412 papers

RefSeq Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell gro...

Pfam Domains

SH2aa 6–81UCSCSH2 domain

SH2aa 112–197UCSCSH2 domain

Y_phosphataseaa 273–520UCSCProtein-tyrosine phosphatase

Gene Aliases

HGNC Name

protein tyrosine phosphatase non-receptor type 11

HGNC Previous Symbol

NS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002834.5

p.V25V

c.75T>C

Surrounding Variants

1 paper

NM_002834.5

p.D26N

c.76G>A

1 paper

NM_002834.5

p.D26H

c.76G>C

1 paper

NM_002834.5

p.D26Y

c.76G>T

1 paper

NM_002834.5

p.V25D

c.74T>A

3 papers

NM_002834.5

p.V25A

c.74T>C

1 paper

NM_002834.5

p.V25G

c.74T>G

3 papers

NM_002834.5

p.D26A

c.77A>C

2 papers

NM_002834.5

p.D26G

c.77A>G

1 paper

NM_002834.5

p.D26V

c.77A>T

2 papers

NM_002834.5

p.V25I

c.73G>A

1 paper

NM_002834.5

p.V25L

c.73G>C

1 paper

NM_002834.5

p.V25F

c.73G>T