Varaico: Literature-Extracted Genetic Variants

PTPN11

3,412 papers

RefSeq Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell gro...

Pfam Domains

SH2aa 6–81UCSCSH2 domain

SH2aa 112–197UCSCSH2 domain

Y_phosphataseaa 273–520UCSCProtein-tyrosine phosphatase

Gene Aliases

HGNC Name

protein tyrosine phosphatase non-receptor type 11

HGNC Previous Symbol

NS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_002834.5

p.D61del1

c.181_182delGAT

Surrounding Variants

13 papers

NM_002834.5

p.G60D

c.179G>A

97 papers

NM_002834.5

p.G60A

c.179G>C

123 papers

NM_002834.5

p.G60V

c.179G>T

2 papers

NM_002834.5

p.G60_D61delins

c.179_182delinsT

12 papers

NM_002834.5

p.G60S

c.178G>A

60 papers

NM_002834.5

p.G60R

c.178G>C

12 papers

NM_002834.5

p.G60C

c.178G>T

118 papers

NM_002834.5

p.D61N

c.181G>A

50 papers

NM_002834.5

p.D61H

c.181G>C

201 papers

NM_002834.5

p.D61Y

c.181G>T

1 paper

NM_002834.5

p.T59T

c.177T>C

46 papers

NM_002834.5

p.D61A

c.182A>C