Varaico: Literature-Extracted Genetic Variants

PTPN11

3,412 papers

RefSeq Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell gro...

Pfam Domains

SH2aa 6–81UCSCSH2 domain

SH2aa 112–197UCSCSH2 domain

Y_phosphataseaa 273–520UCSCProtein-tyrosine phosphatase

Gene Aliases

HGNC Name

protein tyrosine phosphatase non-receptor type 11

HGNC Previous Symbol

NS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_002834.5

p.D156N

c.466G>A

Surrounding Variants

2 papers

NM_002834.5

p.D156G

c.467A>G

1 paper

NM_002834.5

p.D156V

c.467A>T

1 paper

NM_002834.5

p.D155G

c.464A>G

1 paper

NM_002834.5

p.D155V

c.464A>T

4 papers

NM_002834.5

p.D155N

c.463G>A

4 papers

NM_002834.5

p.D155Y

c.463G>T

3 papers

NM_002834.5

p.K157R

c.470A>G

3 papers

NM_002834.5

p.G154D

c.461G>A

2 papers

NM_002834.5

p.G154A

c.461G>C

4 papers

NM_002834.5

p.G154S

c.460G>A

1 paper

NM_002834.5

p.G154R

c.460G>C

2 papers

NM_002834.5

p.G158A

c.473G>C