Varaico: Literature-Extracted Genetic Variants

PTPN11

3,412 papers

RefSeq Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell gro...

Pfam Domains

SH2aa 6–81UCSCSH2 domain

SH2aa 112–197UCSCSH2 domain

Y_phosphataseaa 273–520UCSCProtein-tyrosine phosphatase

Gene Aliases

HGNC Name

protein tyrosine phosphatase non-receptor type 11

HGNC Previous Symbol

NS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002834.5

p.V291G

c.872T>G

Surrounding Variants

1 paper

NM_002834.5

p.V291A

c.872T>C

1 paper

NM_002834.5

p.V291I

c.871G>A

1 paper

NM_002834.5

p.V290D

c.869T>A

1 paper

NM_002834.5

p.V290A

c.869T>C

1 paper

NM_002834.5

p.V290G

c.869T>G

2 papers

NM_002834.5

p.V290I

c.868G>A

2 papers

NM_002834.5

p.V290L

c.868G>C

2 papers

NM_002834.5

p.H293Y

c.877C>T

4 papers

NM_002834.5

p.R289S

c.867G>C

4 papers

NM_002834.5

p.R289S

c.867G>T

2 papers

NM_002834.5

p.R289K

c.866G>A

1 paper

NM_002834.5

p.R289T

c.866G>C