Varaico: Literature-Extracted Genetic Variants

PTPN21

110 papers

RefSeq Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell gro...

Pfam Domains

FERM_Naa 27–90UCSCFERM N-terminal domain

FERM_Maa 106–222UCSCFERM central domain

FERM_Caa 226–312UCSCFERM C-terminal PH-like domain

Y_phosphataseaa 921–1166UCSCProtein-tyrosine phosphatase

Gene Aliases

HGNC Name

protein tyrosine phosphatase non-receptor type 21

HGNC Alias Symbols

PTPD1; PTPRL10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_007039.4

p.G790W

c.2368G>T

Surrounding Variants

1 paper

NM_007039.4

p.G790R

c.2368G>C

1 paper

NM_007039.4

p.G790R

c.2368G>A

1 paper

NM_007039.4

p.S799S

c.2397C>T

1 paper

NM_007039.4

p.D766D

c.2298C>T

1 paper

NM_007039.4

p.V764I

c.2290G>A

1 paper

NM_007039.4

p.P818P

c.2454G>A

1 paper

NM_007039.4

p.L758P

c.2273T>C

1 paper

NM_007039.4

p.H756R

c.2267A>G

2 papers

NM_007039.4

p.A752T

c.2254G>A

1 paper

NM_007039.4

p.R748H

c.2243G>A

1 paper

NM_007039.4

p.D742V

c.2225A>T

1 paper

NM_007039.4

p.P729fs

c.2185_2186fs