Varaico: Literature-Extracted Genetic Variants

PTPN21

110 papers

RefSeq Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell gro...

Pfam Domains

FERM_Naa 27–90UCSCFERM N-terminal domain

FERM_Maa 106–222UCSCFERM central domain

FERM_Caa 226–312UCSCFERM C-terminal PH-like domain

Y_phosphataseaa 921–1166UCSCProtein-tyrosine phosphatase

Gene Aliases

HGNC Name

protein tyrosine phosphatase non-receptor type 21

HGNC Alias Symbols

PTPD1; PTPRL10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_007039.4

p.P447S

c.1339C>T

Surrounding Variants

1 paper

NM_007039.4

p.P442S

c.1324C>T

2 papers

NM_007039.4

p.R436W

c.1306C>T

1 paper

NM_007039.4

p.G461A

c.1382G>C

1 paper

NM_007039.4

p.A465V

c.1394C>T

1 paper

NM_007039.4

p.L472P

c.1415T>C

1 paper

NM_007039.4

p.I421I

c.1263C>T

1 paper

NM_007039.4

p.S416S

c.1248G>A

1 paper

NM_007039.4

p.A482T

c.1444G>A

2 papers

NM_007039.4

p.A487T

c.1459G>A

1 paper

NM_007039.4

p.N405insFs

c.1214dupA

1 paper

NM_007039.4

p.R390H

c.1169G>A

1 paper

NM_007039.4

p.R390C

c.1168C>T