Varaico: Literature-Extracted Genetic Variants

PTPN21

110 papers

RefSeq Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell gro...

Pfam Domains

FERM_Naa 27–90UCSCFERM N-terminal domain

FERM_Maa 106–222UCSCFERM central domain

FERM_Caa 226–312UCSCFERM C-terminal PH-like domain

Y_phosphataseaa 921–1166UCSCProtein-tyrosine phosphatase

Gene Aliases

HGNC Name

protein tyrosine phosphatase non-receptor type 21

HGNC Alias Symbols

PTPD1; PTPRL10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_007039.4

p.Q74E

c.220C>G

Surrounding Variants

2 papers

NM_007039.4

p.Y68C

c.203A>G

1 paper

NM_007039.4

p.L80S

c.239T>C

1 paper

NM_007039.4

p.T62T

c.186T>A

1 paper

NM_007039.4

p.E114del1

c.340_342delCTC

1 paper

NM_007039.4

p.Q119*

c.355C>T

1 paper

NM_007039.4

p.C135fs

c.403_404fs

1 paper

NM_007039.4

p.Q149K

c.445C>A