Varaico: Literature-Extracted Genetic Variants

Gene:PTTG1
Variant:p.S176A

PTTG1

113 papers

RefSeq Summary

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with ...

Pfam Domains

Securinaa 1–191UCSCSecurin sister-chromatid separation inhibitor

Gene Aliases

HGNC Name

PTTG1 regulator of sister chromatid separation, securin

HGNC Previous Symbol

TUTR1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004219.4
p.S176A
c.526T>G
Surrounding Variants
1 paper
NM_004219.4
p.P173L
c.518C>T
1 paper
NM_004219.4
p.P172A
c.514C>G
1 paper
NM_004219.4
p.S171A
c.511T>G
3 papers
NM_004219.4
p.P170L
c.509C>T
1 paper
NM_004219.4
p.P166L
c.497C>T
4 papers
NM_004219.4
p.S165A
c.493T>G
1 paper
NM_004219.4
p.P164R
c.491C>G
1 paper
NM_004219.4
p.P163A
c.487C>G
1 paper
NM_004219.4
p.R153G
c.457A>G
1 paper
NM_004219.4
p.Q135K
c.403C>A
1 paper
NM_004219.4
p.H134R
c.401A>G
1 paper
NM_004219.4
p.F128L
c.384T>A
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