Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002880.4

p.L609L

c.1827C>G

Surrounding Variants

1 paper

NM_002880.4

p.Q610H

c.1830A>C

1 paper

NM_002880.4

p.H611N

c.1831C>A

14 papers

NM_002880.4

p.S612T

c.1834T>A

1 paper

NM_002880.4

p.S612C

c.1835C>G

3 papers

NM_002880.4

p.I606M

c.1818T>G

92 papers

NM_002880.4

p.L613V

c.1837C>G

1 paper

NM_002880.4

p.L613P

c.1838T>C

1 paper

NM_002880.4

p.S604_S605del2

c.1810_1814del6

2 papers

NM_002880.4

p.S605F

c.1814C>T

1 paper

NM_002880.4

p.P614L

c.1841C>T

1 paper

NM_002880.4

p.S604C

c.1811C>G

7 papers

NM_002880.4

p.L603P

c.1808T>C