Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002880.4

p.E540K

c.1618G>A

Surrounding Variants

1 paper

NM_002880.4

p.E540Q

c.1618G>C

1 paper

NM_002880.4

p.Y539F

c.1616A>T

1 paper

NM_002880.4

p.L541ins1

c.1622_1623insACC

1 paper

NM_002880.4

p.M542T

c.1625T>C

1 paper

NM_002880.4

p.V537L

c.1609G>T

1 paper

NM_002880.4

p.V537L

c.1609G>C

6 papers

NM_002880.4

p.V537I

c.1609G>A

2 papers

NM_002880.4

p.T543A

c.1627A>G

2 papers

NM_002880.4

p.T543M

c.1628C>T

1 paper

NM_002880.4

p.G544G

c.1632G>C

1 paper

NM_002880.4

p.G535D

c.1604G>A

1 paper

NM_002880.4

p.E545Q

c.1633G>C