Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002880.4

p.S526R

c.1576A>C

Surrounding Variants

1 paper

NM_002880.4

p.F525L

c.1575C>G

1 paper

NM_002880.4

p.F525L

c.1575C>A

1 paper

NM_002880.4

p.F525L

c.1573T>C

1 paper

NM_002880.4

p.S529L

c.1586C>T

1 paper

NM_002880.4

p.D530N

c.1588G>A

1 paper

NM_002880.4

p.M519T

c.1556T>C

3 papers

NM_002880.4

p.R518Q

c.1553G>A

1 paper

NM_002880.4

p.G535D

c.1604G>A

1 paper

NM_002880.4

p.V537L

c.1609G>T

1 paper

NM_002880.4

p.V537L

c.1609G>C

6 papers

NM_002880.4

p.V537I

c.1609G>A

1 paper

NM_002880.4

p.P514delFs

c.1541_1542delTG