Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002880.4

p.L510V

c.1528C>G

Surrounding Variants

1 paper

NM_002880.4

p.S508insFs

c.1523_1524ins5

1 paper

NM_002880.4

p.G507C

c.1519G>T

1 paper

NM_002880.4

p.T506I

c.1517C>T

2 papers

NM_002880.4

p.T506A

c.1516A>G

1 paper

NM_002880.4

p.P505S

c.1513C>T

2 papers

NM_002880.4

p.E503Q

c.1507G>C

2 papers

NM_002880.4

p.E503K

c.1507G>A

1 paper

NM_002880.4

p.Q501R

c.1502A>G

1 paper

NM_002880.4

p.Q501*

c.1501C>T

1 paper

NM_002880.4

p.S499F

c.1496C>T

4 papers

NM_002880.4

p.S499A

c.1495T>G

1 paper

NM_002880.4

p.G498V

c.1493G>T