Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_002880.4

p.F475L

c.1425T>A

Surrounding Variants

2 papers

NM_002880.4

p.F475L

c.1425T>G

1 paper

NM_002880.4

p.L476F

c.1426C>T

1 paper

NM_002880.4

p.L476I

c.1426C>A

2 papers

NM_002880.4

p.F475L

c.1423T>C

1 paper

NM_002880.4

p.I474L

c.1420A>T

1 paper

NM_001354689.3

p.H497R

c.1490A>G

1 paper

NM_002880.4

p.I474V

c.1420A>G

1 paper

NM_002880.4

p.I474L

c.1420A>C

25 papers

NM_002880.4

p.E478K

c.1432G>A

1 paper

NM_002880.4

p.N473S

c.1418A>G

2 papers

NM_002880.4

p.G479D

c.1436G>A

3 papers

NM_002880.4

p.T481A

c.1441A>G